Fractyl Health (GUTS) Stock Price, News & Analysis

Company Overview

Fractyl Health, Inc., a metabolic therapeutics company, develops therapies for the treatment of type 2 diabetes (T2D) and obesity. The company develops Revita DMR System (Revita), an outpatient procedural therapy designed to durably modify duodenal dysfunction, a pathologic consequence of a high fat and high sugar diet, which can initiate T2D and obesity in humans. It also develops Rejuva, a novel adeno-associated virus delivered pancreatic gene therapy platform that is designed to enable long-term remission of T2D and obesity by durably altering metabolic hormone function in the pancreatic islet cells of patients. Fractyl Health, Inc. was formerly known as Fractyl Laboratories Inc. and changed its name to Fractyl Health, Inc. on June 09, 2021. The company was incorporated in 2010 and is headquartered in Burlington, Massachusetts.

Key Stats

• Today's Range: $0.95 to $1.02
• 50-Day Range: $0.96 to $2.17
• 52-Week Range: $0.83 to $3.72
• Volume: 545,900 shs
• Average Volume: 493,021 shs
• Market Capitalization: $49.99 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $8.00
• Consensus Rating: Buy

Fractyl Health Stock Analysis - MarketRank™

Fractyl Health scored higher than 38% of companies evaluated by MarketBeat, and ranked 718th out of 937 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.5 / 5
• Analyst Rating: Buy

Consensus Rating

Fractyl Health has received a consensus rating of Buy. The company's average rating score is 3.00, and is based on 2 buy ratings, no hold ratings, and no sell ratings.

Amount of Analyst Coverage

Fractyl Health has only been the subject of 1 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Fractyl Health are expected to decrease in the coming year, from ($1.61) to ($1.81) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Fractyl Health is -0.49, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Fractyl Health is -0.49, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Short Interest

• Score: 2.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

9.58% of the float of Fractyl Health has been sold short.

Short Interest Ratio / Days to Cover

Fractyl Health has a short interest ratio ("days to cover") of 2.8, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Fractyl Health has recently increased by 5.82%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Fractyl Health does not currently pay a dividend.

Dividend Growth

Fractyl Health does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

9.58% of the float of Fractyl Health has been sold short.

Short Interest Ratio / Days to Cover

Fractyl Health has a short interest ratio ("days to cover") of 2.8, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Fractyl Health has recently increased by 5.82%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 1.5 / 5
• News Sentiment: -0.25

News Sentiment

Fractyl Health has a news sentiment score of -0.25. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.50 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 4 news articles for Fractyl Health this week, compared to 2 articles on an average week.

Search Interest

7 people have searched for GUTS on MarketBeat in the last 30 days. This is an increase of 40% compared to the previous 30 days.

MarketBeat Follows

Only 2 people have added Fractyl Health to their MarketBeat watchlist in the last 30 days. This is a decrease of -33% compared to the previous 30 days.

Company Ownership

• Score: 1.7 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Fractyl Health insiders have not sold or bought any company stock.

Percentage Held by Insiders

27.00% of the stock of Fractyl Health is held by insiders. A high percentage of insider ownership can be a sign of company health.

GUTS Stock Analysis - Frequently Asked Questions

How have GUTS shares performed this year?

Fractyl Health's stock was trading at $2.06 at the beginning of 2025. Since then, GUTS stock has decreased by 51.2% and is now trading at $1.0050.

How were Fractyl Health's earnings last quarter?

Fractyl Health, Inc. (NASDAQ:GUTS) announced its quarterly earnings results on Tuesday, August, 12th. The company reported ($0.53) earnings per share (EPS) for the quarter, missing the consensus estimate of ($0.37) by $0.16. Fractyl Health had a negative net margin of 73,864.52% and a negative trailing twelve-month return on equity of 584.35%.
Read the conference call transcript.

When did Fractyl Health IPO?

Fractyl Health (GUTS) raised $110 million in an IPO on Friday, February 2nd 2024. The company issued 7,333,333 shares at a price of $15.00 per share.

Who are Fractyl Health's major shareholders?

Top institutional shareholders of Fractyl Health include General Catalyst Group Management LLC (9.97%), Y Intercept Hong Kong Ltd (0.23%), Geode Capital Management LLC (0.23%) and Qube Research & Technologies Ltd (0.16%). Insiders that own company stock include Ajay Royan, Harith Rajagopalan, Jay David Caplan and William Bradley.
View institutional ownership trends.

How do I buy shares of Fractyl Health?

Shares of GUTS stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Fractyl Health own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Fractyl Health investors own include SoFi Technologies (SOFI), NVIDIA (NVDA), Meta Platforms (META), Tesla (TSLA), Alphabet (GOOG), JPMorgan Chase & Co. (JPM) and Advanced Micro Devices (AMD).

Company Calendar

• Last Earnings: 8/12/2025
• Today: 8/21/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - DRUGS
• Sub-Industry: Medical Equipment
• Current Symbol: NASDAQ:GUTS
• Previous Symbol: NASDAQ:GUTS
• CIK: 1572616
• Web: fractyl.com
• Phone: 781-902-8800
• Fax: N/A
• Employees: 102
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Fractyl Health: $8.00
• High Price Target: $10.00
• Low Price Target: $6.00
• Potential Upside/Downside: +716.3%
• Consensus Rating: Buy
• Rating Score (0-4): 3.00
• Research Coverage: 2 Analysts

Profitability

• EPS (Trailing Twelve Months): ($2.06)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$68.69 million
• Net Margins: -73,864.52%
• Pretax Margin: -586,864.69%
• Return on Equity: -584.35%
• Return on Assets: -102.88%

Debt

• Debt-to-Equity Ratio: 4.61
• Current Ratio: 1.22
• Quick Ratio: 1.22

Sales & Book Value

• Annual Sales: $90 thousand
• Price / Sales: 547.60
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: ($0.36) per share
• Price / Book: -2.72

Miscellaneous

• Outstanding Shares: 50,290,000
• Free Float: 36,711,000
• Market Cap: $49.28 million
• Optionable: N/A
• Beta: 1.66