Praxis Precision Medicines (PRAX) Stock Price, News & Analysis

Company Overview

Praxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for central nervous system disorders characterized by neuronal excitation-inhibition imbalance. It is developing ulixacaltamide, a small molecule inhibitor of T-type calcium channels that is in Phase III clinical trial for the treatment of essential tremor; PRAX-562 for the treatment of pediatric patients with developmental and epileptic encephalopathies (DEE); and PRAX-628 to treat focal epilepsy. The company also develops PRAX-222 for the treatment of pediatric patients with early-onset SCN2A-DEE; PRAX-020 to treat KCNT1 related epilepsies; PRAX-080 for the treatment of PCDH19; and PRAX-090 and PRAX-100 for SYNGAP1 and SCN2A-LoF. It has a license agreement with RogCon Inc.; a research collaboration and license agreement with Ionis Pharmaceuticals, Inc.; a strategic collaboration and license agreement with UCB Biopharma SRL; and collaboration with The Florey Institute to develop three novel ASOs. The company was incorporated in 2015 and is based in Boston, Massachusetts.

Key Stats

• Today's Range: $45.72 to $48.40
• 50-Day Range: $41.63 to $59.22
• 52-Week Range: $26.70 to $91.83
• Volume: 108,562 shs
• Average Volume: 447,137 shs
• Market Capitalization: $958.93 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $85.88
• Consensus Rating: Moderate Buy

Praxis Precision Medicines Stock Analysis - MarketRank™

Praxis Precision Medicines scored higher than 34% of companies evaluated by MarketBeat, and ranked 781st out of 945 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.4 / 5
• Analyst Rating: Moderate Buy

Consensus Rating

Praxis Precision Medicines has received a consensus rating of Moderate Buy. The company's average rating score is 2.75, and is based on 7 buy ratings, no hold ratings, and 1 sell rating.

Amount of Analyst Coverage

Praxis Precision Medicines has only been the subject of 4 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Praxis Precision Medicines are expected to decrease in the coming year, from ($10.22) to ($12.22) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Praxis Precision Medicines is -3.80, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Praxis Precision Medicines is -3.80, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Praxis Precision Medicines has a P/B Ratio of 2.43. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.

Short Interest

• Score: 1.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

11.26% of the float of Praxis Precision Medicines has been sold short.

Short Interest Ratio / Days to Cover

Praxis Precision Medicines has a short interest ratio ("days to cover") of 5.4.

Change versus previous month

Short interest in Praxis Precision Medicines has recently increased by 9.28%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Praxis Precision Medicines does not currently pay a dividend.

Dividend Growth

Praxis Precision Medicines does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

11.26% of the float of Praxis Precision Medicines has been sold short.

Short Interest Ratio / Days to Cover

Praxis Precision Medicines has a short interest ratio ("days to cover") of 5.4.

Change versus previous month

Short interest in Praxis Precision Medicines has recently increased by 9.28%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 2.7 / 5
• News Sentiment: 0.80

News Sentiment

Praxis Precision Medicines has a news sentiment score of 0.80. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.99 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 10 news articles for Praxis Precision Medicines this week, compared to 6 articles on an average week.

Search Interest

Only 6 people have searched for PRAX on MarketBeat in the last 30 days. This is a decrease of -25% compared to the previous 30 days.

MarketBeat Follows

3 people have added Praxis Precision Medicines to their MarketBeat watchlist in the last 30 days.

Company Ownership

• Score: 1.7 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Praxis Precision Medicines insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 2.70% of the stock of Praxis Precision Medicines is held by insiders.

Percentage Held by Institutions

67.84% of the stock of Praxis Precision Medicines is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

PRAX Stock Analysis - Frequently Asked Questions

How have PRAX shares performed this year?

Praxis Precision Medicines' stock was trading at $76.96 at the beginning of the year. Since then, PRAX shares have decreased by 39.5% and is now trading at $46.5870.

How were Praxis Precision Medicines' earnings last quarter?

Praxis Precision Medicines, Inc. (NASDAQ:PRAX) issued its quarterly earnings data on Monday, August, 4th. The company reported ($3.31) earnings per share (EPS) for the quarter, beating the consensus estimate of ($3.40) by $0.09. Praxis Precision Medicines had a negative trailing twelve-month return on equity of 60.07% and a negative net margin of 2,137.48%.
Read the conference call transcript.

When did Praxis Precision Medicines' stock split?

Praxis Precision Medicines shares reverse split before market open on Wednesday, November 29th 2023.The 1-15 reverse split was announced on Wednesday, November 29th 2023. The number of shares owned by shareholders was adjusted after the closing bell on Wednesday, November 29th 2023. An investor that had 100 shares of stock prior to the reverse split would have 7 shares after the split.

When did Praxis Precision Medicines IPO?

Praxis Precision Medicines (PRAX) raised $126 million in an initial public offering on Friday, October 16th 2020. The company issued 7,400,000 shares at $16.00-$18.00 per share. Cowen, Evercore ISI, Piper Sandler and Wedbush PacGrow served as the underwriters for the IPO and Blackstone Capital Markets was co-manager.

Who are Praxis Precision Medicines' major shareholders?

Praxis Precision Medicines' top institutional shareholders include Adage Capital Partners GP L.L.C. (9.38%), Soleus Capital Management L.P. (4.59%), Perceptive Advisors LLC (3.58%) and Assenagon Asset Management S.A. (2.97%). Insiders that own company stock include Alex Nemiroff, Lauren Mastrocola, Dean J Mitchell, Marcio Souza and Jill Desimone.
View institutional ownership trends.

How do I buy shares of Praxis Precision Medicines?

Shares of PRAX stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Praxis Precision Medicines own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Praxis Precision Medicines investors own include NVIDIA (NVDA), Broadcom (AVGO), Meta Platforms (META), Advanced Micro Devices (AMD), Adobe (ADBE), Arista Networks (ANET) and ServiceNow (NOW).

Company Calendar

• Last Earnings: 8/04/2025
• Today: 8/28/2025
• Next Earnings (Estimated): 11/05/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:PRAX
• CIK: 1689548
• Web: www.praxismedicines.com
• Phone: 617-300-8460
• Fax: N/A
• Employees: 110
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Praxis Precision Medicines: $85.88
• High Price Target: $115.00
• Low Price Target: $28.00
• Potential Upside/Downside: +84.3%
• Consensus Rating: Moderate Buy
• Rating Score (0-4): 2.75
• Research Coverage: 8 Analysts

Profitability

• EPS (Trailing Twelve Months): ($12.29)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$182.82 million
• Net Margins: -2,137.48%
• Pretax Margin: -3,232.61%
• Return on Equity: -60.07%
• Return on Assets: -54.84%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 6.31
• Quick Ratio: 6.31

Sales & Book Value

• Annual Sales: $8.55 million
• Price / Sales: 114.70
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $19.21 per share
• Price / Book: 2.43

Miscellaneous

• Outstanding Shares: 21,050,000
• Free Float: 20,478,000
• Market Cap: $980.66 million
• Optionable: Optionable
• Beta: 2.62