Spero Therapeutics (SPRO) Competitors $0.86 -0.03 (-3.36%) Closing price 04:00 PM EasternExtended Trading$0.83 -0.03 (-3.50%) As of 06:33 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock SPRO vs. OCGN, CYBN, IKT, TLSA, LRMR, MOLN, PBYI, GLSI, NBTX, and NLTXShould you be buying Spero Therapeutics stock or one of its competitors? The main competitors of Spero Therapeutics include Ocugen (OCGN), Cybin (CYBN), Inhibikase Therapeutics (IKT), Tiziana Life Sciences (TLSA), Larimar Therapeutics (LRMR), Molecular Partners (MOLN), Puma Biotechnology (PBYI), Greenwich LifeSciences (GLSI), Nanobiotix (NBTX), and Neoleukin Therapeutics (NLTX). These companies are all part of the "pharmaceutical products" industry. Spero Therapeutics vs. Ocugen Cybin Inhibikase Therapeutics Tiziana Life Sciences Larimar Therapeutics Molecular Partners Puma Biotechnology Greenwich LifeSciences Nanobiotix Neoleukin Therapeutics Spero Therapeutics (NASDAQ:SPRO) and Ocugen (NASDAQ:OCGN) are both small-cap medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their risk, earnings, institutional ownership, profitability, dividends, analyst recommendations, community ranking, media sentiment and valuation. Which has more volatility & risk, SPRO or OCGN? Spero Therapeutics has a beta of 0.68, meaning that its share price is 32% less volatile than the S&P 500. Comparatively, Ocugen has a beta of 3.88, meaning that its share price is 288% more volatile than the S&P 500. Do analysts recommend SPRO or OCGN? Spero Therapeutics presently has a consensus price target of $5.00, indicating a potential upside of 464.33%. Ocugen has a consensus price target of $6.33, indicating a potential upside of 785.78%. Given Ocugen's stronger consensus rating and higher probable upside, analysts plainly believe Ocugen is more favorable than Spero Therapeutics.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Spero Therapeutics 0 Sell rating(s) 2 Hold rating(s) 2 Buy rating(s) 0 Strong Buy rating(s) 2.50Ocugen 0 Sell rating(s) 0 Hold rating(s) 3 Buy rating(s) 0 Strong Buy rating(s) 3.00 Do institutionals and insiders hold more shares of SPRO or OCGN? 25.6% of Spero Therapeutics shares are held by institutional investors. Comparatively, 10.3% of Ocugen shares are held by institutional investors. 4.5% of Spero Therapeutics shares are held by company insiders. Comparatively, 4.3% of Ocugen shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth. Does the media prefer SPRO or OCGN? In the previous week, Spero Therapeutics and Spero Therapeutics both had 2 articles in the media. Ocugen's average media sentiment score of 0.94 beat Spero Therapeutics' score of 0.93 indicating that Ocugen is being referred to more favorably in the news media. Company Overall Sentiment Spero Therapeutics Positive Ocugen Positive Which has higher earnings and valuation, SPRO or OCGN? Spero Therapeutics has higher revenue and earnings than Ocugen. Ocugen is trading at a lower price-to-earnings ratio than Spero Therapeutics, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioSpero Therapeutics$89.87M0.54$22.81M$0.0712.66Ocugen$4.06M51.49-$63.08M-$0.19-3.76 Is SPRO or OCGN more profitable? Spero Therapeutics has a net margin of 3.30% compared to Ocugen's net margin of -532.51%. Spero Therapeutics' return on equity of 4.03% beat Ocugen's return on equity.Company Net Margins Return on Equity Return on Assets Spero Therapeutics3.30% 4.03% 2.21% Ocugen -532.51%-154.75%-90.79% Does the MarketBeat Community believe in SPRO or OCGN? Spero Therapeutics received 96 more outperform votes than Ocugen when rated by MarketBeat users. However, 71.07% of users gave Ocugen an outperform vote while only 69.67% of users gave Spero Therapeutics an outperform vote. CompanyUnderperformOutperformSpero TherapeuticsOutperform Votes20969.67% Underperform Votes9130.33% OcugenOutperform Votes11371.07% Underperform Votes4628.93% SummarySpero Therapeutics beats Ocugen on 10 of the 17 factors compared between the two stocks. Remove Ads Get Spero Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for SPRO and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding {thisCompany.Symbol} and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SPRO vs. The Competition Export to ExcelMetricSpero TherapeuticsPharmaceutical IndustryMedical SectorNASDAQ ExchangeMarket Cap$48.63M$6.92B$5.64B$8.16BDividend YieldN/A2.73%4.56%4.02%P/E Ratio12.747.2424.5519.12Price / Sales0.54226.41379.5993.71Price / Cash1.6265.6738.1634.64Price / Book0.446.526.984.38Net Income$22.81M$142.41M$3.20B$247.23M7 Day Performance13.94%-2.78%-2.04%-0.20%1 Month Performance13.60%-4.36%3.32%-3.45%1 Year Performance-49.37%-8.10%11.56%2.41% Spero Therapeutics Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SPROSpero Therapeutics4.5375 of 5 stars$0.86-3.4%$5.00+481.3%-48.6%$46.89M$89.87M12.29150Earnings ReportNews CoverageOCGNOcugen1.285 of 5 stars$0.57+6.1%$6.33+1,011.1%-57.3%$166.45M$4.06M-3.1780Analyst RevisionCYBNCybin2.9328 of 5 stars$7.65+1.1%$86.00+1,024.2%N/A$164.30MN/A-1.7550IKTInhibikase Therapeutics0.9852 of 5 stars$2.36+4.9%$6.50+175.4%+4.4%$163.69M$260,000.00-0.886News CoverageTLSATiziana Life Sciences0.6458 of 5 stars$1.55-1.3%N/A+177.5%$163.36MN/A0.008Short Interest ↑Positive NewsGap UpLRMRLarimar Therapeutics1.9892 of 5 stars$2.55-1.5%$20.13+689.2%-68.8%$162.71MN/A-2.2230Earnings ReportAnalyst ForecastAnalyst RevisionNews CoverageGap UpMOLNMolecular Partners2.3422 of 5 stars$4.03-7.0%$12.00+198.1%+10.8%$162.46M$4.97M-1.87180Gap DownPBYIPuma Biotechnology4.3751 of 5 stars$3.24-2.4%$7.00+116.0%-44.1%$160.74M$230.47M6.75200Positive NewsGLSIGreenwich LifeSciences2.2424 of 5 stars$12.21+1.8%$38.00+211.2%-47.7%$160.50MN/A-15.263News CoverageGap UpNBTXNanobiotix2.4476 of 5 stars$3.33+2.8%$12.00+260.4%-44.2%$156.95M$36.22M0.00100Short Interest ↓News CoverageGap UpNLTXNeoleukin TherapeuticsN/A$16.70-0.6%N/A-71.8%$156.95MN/A-5.3790High Trading Volume Remove Ads Related Companies and Tools Related Companies Ocugen Alternatives Cybin Alternatives Inhibikase Therapeutics Alternatives Tiziana Life Sciences Alternatives Larimar Therapeutics Alternatives Molecular Partners Alternatives Puma Biotechnology Alternatives Greenwich LifeSciences Alternatives Nanobiotix Alternatives Neoleukin Therapeutics Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SPRO) was last updated on 3/27/2025 by MarketBeat.com Staff From Our PartnersA market crash is coming—here’s whenThe stock market cycle I've used to identify the most likely day of the next market crash is the exact same in...Chaikin Analytics | SponsoredYour Wealth is Under AttackPlease don't wait—this is your moment to take action. 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