| 2/19/2025 | Toronto Dominion Bank | 3,173,258 | $35.00M | 0.1% | N/A | 5.991% | |
| 2/17/2025 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 95,505 | $1.05M | 0.0% | +123.7% | 0.180% | |
| 2/17/2025 | Voloridge Investment Management LLC | 86,888 | $958K | 0.0% | -29.4% | 0.164% | |
| 2/17/2025 | Squarepoint Ops LLC | 120,242 | $1.33M | 0.0% | +6.7% | 0.227% | |
| 2/17/2025 | Two Sigma Investments LP | 53,950 | $595K | 0.0% | -53.8% | 0.102% | |
| 2/17/2025 | Tang Capital Management LLC | 300,000 | $3.31M | 0.2% | N/A | 0.566% | |
| 2/17/2025 | Toronto Dominion Bank | 3,173,258 | $35.00M | 0.1% | N/A | 5.991% | |
| 2/17/2025 | RTW Investments LP | 5,123,525 | $56.51M | 0.9% | +10.1% | 9.673% | |
| 2/17/2025 | Rafferty Asset Management LLC | 67,227 | $742K | 0.0% | -18.8% | 0.127% | |
| 2/17/2025 | Redmile Group LLC | 4,593,629 | $50.67M | 3.5% | -2.5% | 8.672% | |
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| 2/17/2025 | ProShare Advisors LLC | 12,626 | $139K | 0.0% | N/A | 0.024% | |
| 2/17/2025 | MPM Bioimpact LLC | 685,826 | $7.57M | 1.1% | +43.0% | 1.295% | |
| 2/17/2025 | Millennium Management LLC | 76,829 | $847K | 0.0% | +417.9% | 0.145% | |
| 2/17/2025 | Group One Trading LLC | 104,411 | $1.15M | 0.0% | +2.8% | 0.197% | |
| 2/17/2025 | Graham Capital Management L.P. | 18,634 | $206K | 0.0% | +8.5% | 0.035% | |
| 2/17/2025 | Granahan Investment Management LLC | 567,689 | $6.26M | 0.3% | -12.0% | 1.072% | |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 28,043 | $309K | 0.0% | -83.6% | 0.053% | |
| 2/17/2025 | Deutsche Bank AG | 350,614 | $3.87M | 0.0% | -24.2% | 0.662% | |
| 2/17/2025 | DAFNA Capital Management LLC | 171,097 | $1.89M | 0.5% | -17.5% | 0.323% | |
| 2/17/2025 | Baker BROS. Advisors LP | 4,633,838 | $51.11M | 0.5% | +6.1% | 8.748% | |
| 2/17/2025 | Bank of America Corp DE | 9,091 | $100K | 0.0% | -92.7% | 0.017% | |
| 2/17/2025 | BNP Paribas Financial Markets | 4,422 | $49K | 0.0% | -94.2% | 0.008% | |
| 2/17/2025 | Ameriprise Financial Inc. | 10,527 | $116K | 0.0% | -26.5% | 0.020% | |
| 2/14/2025 | Jane Street Group LLC | 11,977 | $132K | 0.0% | -96.4% | 0.023% | |
| 2/14/2025 | Freestone Grove Partners LP | 18,049 | $199K | 0.0% | N/A | 0.034% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 291,795 | $3.22M | 0.0% | N/A | 0.551% | |
| 2/14/2025 | Northern Trust Corp | 350,788 | $3.87M | 0.0% | +3.4% | 0.662% | |
| 2/14/2025 | Tudor Investment Corp ET AL | 18,258 | $201K | 0.0% | N/A | 0.034% | |
| 2/14/2025 | Gilder Gagnon Howe & Co. LLC | 92,546 | $1.02M | 0.0% | +2.0% | 0.175% | |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 37,455 | $414K | 0.0% | +6.3% | 0.071% | |
| 2/14/2025 | Tower Research Capital LLC TRC | 11,930 | $132K | 0.0% | +70.1% | 0.023% | |
| 2/14/2025 | Dimensional Fund Advisors LP | 538,900 | $5.94M | 0.0% | +103.4% | 1.017% | |
| 2/13/2025 | CANADA LIFE ASSURANCE Co | 9,716 | $107K | 0.0% | -14.4% | 0.018% | |
| 2/13/2025 | Marshall Wace LLP | 951,432 | $10.49M | 0.0% | -43.1% | 1.796% | |
| 2/13/2025 | Renaissance Technologies LLC | 129,043 | $1.42M | 0.0% | N/A | 0.244% | |
| 2/13/2025 | Legal & General Group Plc | 35,347 | $390K | 0.0% | -5.7% | 0.067% | |
| 2/13/2025 | Invesco Ltd. | 12,065 | $133K | 0.0% | N/A | 0.023% | |
| 2/13/2025 | Wells Fargo & Company MN | 16,786 | $185K | 0.0% | +51.2% | 0.032% | |
| 2/12/2025 | Trexquant Investment LP | 103,031 | $1.14M | 0.0% | -36.3% | 0.195% | |
| 2/12/2025 | Geode Capital Management LLC | 877,095 | $9.68M | 0.0% | +0.7% | 1.656% | |
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| 2/12/2025 | Wellington Management Group LLP | 134,812 | $1.49M | 0.0% | -1.6% | 0.255% | |
| 2/12/2025 | Norges Bank | 314,800 | $3.47M | 0.0% | N/A | 0.594% | |
| 2/12/2025 | JPMorgan Chase & Co. | 19,964 | $220K | 0.0% | +29.2% | 0.038% | |
| 2/11/2025 | EntryPoint Capital LLC | 31,968 | $353K | 0.1% | N/A | 0.060% | |
| 2/11/2025 | Corebridge Financial Inc. | 17,861 | $197K | 0.0% | -6.1% | 0.034% | |
| 2/11/2025 | Vanguard Group Inc. | 2,731,198 | $30.13M | 0.0% | -1.0% | 5.156% | |
| 2/11/2025 | KLP Kapitalforvaltning AS | 5,700 | $63K | 0.0% | N/A | 0.011% | |
| 2/11/2025 | Teacher Retirement System of Texas | 10,219 | $113K | 0.0% | N/A | 0.019% | |
| 2/10/2025 | Swiss National Bank | 67,300 | $742K | 0.0% | +20.4% | 0.127% | |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 342,129 | $3.77M | 0.0% | +8.2% | 0.646% | |
| 2/5/2025 | Skorpios Trust | 6,906,181 | $76.18M | 99.8% | -22.5% | 13.038% | |
| 2/4/2025 | Los Angeles Capital Management LLC | 43,438 | $479K | 0.0% | -57.8% | 0.082% | |
| 2/4/2025 | Bank of New York Mellon Corp | 93,195 | $1.03M | 0.0% | +1.4% | 0.176% | |
| 1/30/2025 | Rhumbline Advisers | 49,374 | $545K | 0.0% | +6.0% | 0.093% | |
| 1/24/2025 | China Universal Asset Management Co. Ltd. | 11,231 | $124K | 0.0% | N/A | 0.021% | |
| 1/17/2025 | SG Americas Securities LLC | 10,768 | $119K | 0.0% | -27.8% | 0.020% | |
| 1/14/2025 | Assenagon Asset Management S.A. | 1,350,925 | $14.90M | 0.0% | +2.9% | 2.551% | |
| 12/13/2024 | Exome Asset Management LLC | 176,600 | $2.17M | 1.5% | N/A | 0.333% | |
| 11/27/2024 | Franklin Resources Inc. | 22,314 | $285K | 0.0% | -98.2% | 0.042% | |
| 11/19/2024 | Barclays PLC | 79,740 | $980K | 0.0% | +145.3% | 0.151% | |
| 11/16/2024 | Geode Capital Management LLC | 870,831 | $10.71M | 0.0% | +9.7% | 1.644% | |
| 11/15/2024 | Barclays PLC | 79,740 | $980K | 0.0% | +145.3% | 0.151% | |
| 11/15/2024 | Jane Street Group LLC | 330,442 | $4.06M | 0.0% | +338.2% | 0.624% | |
| 11/15/2024 | Wellington Management Group LLP | 136,975 | $1.68M | 0.0% | -4.6% | 0.259% | |
| 11/15/2024 | State Street Corp | 1,728,888 | $21.25M | 0.0% | +8.6% | 3.264% | |
| 11/15/2024 | RTW Investments LP | 4,652,285 | $57.18M | 0.8% | +10.1% | 8.783% | |
| 11/15/2024 | Redmile Group LLC | 4,713,509 | $57.93M | 3.4% | -0.2% | 8.898% | |
| 11/15/2024 | Checkpoint Capital L.P. | 157,514 | $1.94M | 1.0% | N/A | 0.297% | |
| 11/14/2024 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 42,692 | $525K | 0.0% | -25.6% | 0.081% | |
| 11/13/2024 | BNP Paribas Financial Markets | 76,154 | $936K | 0.0% | +1,589.7% | 0.144% | |
| 11/13/2024 | FMR LLC | 322,949 | $3.97M | 0.0% | -18.9% | 0.610% | |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 316,134 | $3.89M | 0.0% | +9.3% | 0.597% | |
| 11/9/2024 | Intech Investment Management LLC | 13,052 | $160K | 0.0% | N/A | 0.025% | |
| 11/4/2024 | Los Angeles Capital Management LLC | 103,005 | $1.27M | 0.0% | +54.3% | 0.196% | |
| 11/2/2024 | Mesirow Financial Investment Management Inc. | 15,604 | $192K | 0.0% | N/A | 0.030% | |
| 10/23/2024 | Skorpios Trust | 8,906,181 | $109.46M | 99.8% | -17.9% | 16.916% | |
| 10/23/2024 | Assenagon Asset Management S.A. | 1,312,479 | $16.13M | 0.0% | -10.6% | 2.493% | |
| 10/3/2024 | SG Americas Securities LLC | 14,917 | $183K | 0.0% | -78.3% | 0.029% | |
| 9/20/2024 | Healthcare of Ontario Pension Plan Trust Fund | 1,387,200 | $18.74M | 0.1% | +426.1% | 2.635% | |
| 9/4/2024 | Ghisallo Capital Management LLC | 15,000 | $203K | 0.0% | -50.0% | 0.028% | |
| 8/15/2024 | Lynx1 Capital Management LP | 5,185,191 | $70.05M | 25.3% | +40.3% | 9.848% | |
| 8/15/2024 | The Manufacturers Life Insurance Company | 13,964 | $189K | 0.0% | +16.7% | 0.027% | |
| 8/15/2024 | Millennium Management LLC | 289,067 | $3.91M | 0.0% | +528.6% | 0.549% | |
| 8/14/2024 | Squarepoint Ops LLC | 15,042 | $203K | 0.0% | -70.6% | 0.029% | |
| 8/14/2024 | Marshall Wace LLP | 1,161,037 | $15.69M | 0.0% | +550.1% | 2.205% | |
| 8/14/2024 | Logos Global Management LP | 1,050,000 | $14.19M | 1.1% | N/A | 1.994% | |
| 8/14/2024 | Profund Advisors LLC | 14,893 | $201K | 0.0% | N/A | 0.028% | |
| 8/9/2024 | Renaissance Technologies LLC | 11,200 | $151K | 0.0% | -41.4% | 0.021% | |
| 8/9/2024 | Dimensional Fund Advisors LP | 191,360 | $2.59M | 0.0% | -12.9% | 0.367% | |
| 8/8/2024 | American Century Companies Inc. | 59,149 | $799K | 0.0% | +99.4% | 0.113% | |
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| 8/6/2024 | Quest Partners LLC | 2,110 | $29K | 0.0% | N/A | 0.004% | |
| 8/6/2024 | Los Angeles Capital Management LLC | 66,765 | $902K | 0.0% | +7.2% | 0.128% | |
| 8/1/2024 | Rhumbline Advisers | 47,860 | $647K | 0.0% | +14.3% | 0.092% | |
| 7/29/2024 | Zurcher Kantonalbank Zurich Cantonalbank | 9,129 | $123K | 0.0% | N/A | 0.018% | |
| 7/26/2024 | Bank of New York Mellon Corp | 115,892 | $1.57M | 0.0% | +28.9% | 0.222% | |
| 7/20/2024 | Nisa Investment Advisors LLC | 2,989 | $40K | 0.0% | +53.2% | 0.006% | |
| 7/18/2024 | Assenagon Asset Management S.A. | 1,468,202 | $19.84M | 0.0% | N/A | 2.817% | |
| 7/12/2024 | SG Americas Securities LLC | 68,601 | $927K | 0.0% | +610.3% | 0.132% | |
| 5/30/2024 | Lynx1 Capital Management LP | 3,696,820 | $49.91M | 12.9% | +25.0% | 7.093% | |
| 5/17/2024 | Artal Group S.A. | 300,000 | $4.05M | 0.1% | N/A | 0.576% | |
