| 2/17/2025 | Parkman Healthcare Partners LLC | 152,973 | $512K | 0.1% | -24.6% | 1.037% | |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 245,800 | $823K | 0.1% | N/A | 1.666% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 36,958 | $124K | 0.0% | N/A | 0.251% | |
| 2/17/2025 | Acorn Capital Advisors LLC | 456,970 | $1.53M | 0.8% | N/A | 3.098% | |
| 2/14/2025 | Jane Street Group LLC | 20,286 | $68K | 0.0% | N/A | 0.138% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 176,658 | $592K | 0.0% | +4.8% | 1.198% | |
| 2/14/2025 | Northern Trust Corp | 23,971 | $80K | 0.0% | -35.7% | 0.163% | |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 154,134 | $516K | 0.0% | N/A | 1.045% | |
| 2/13/2025 | XTX Topco Ltd | 21,018 | $70K | 0.0% | N/A | 0.142% | |
| 2/13/2025 | Renaissance Technologies LLC | 24,943 | $84K | 0.0% | -71.2% | 0.169% | |
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| 11/15/2024 | Parkman Healthcare Partners LLC | 202,973 | $382K | 0.0% | -41.2% | 1.376% | |
| 10/30/2024 | AlphaCentric Advisors LLC | 268,485 | $505K | 0.4% | -13.5% | 1.820% | |
| 8/15/2024 | Lynx1 Capital Management LP | 16,194 | $32K | 0.0% | N/A | 0.111% | |
| 8/9/2024 | Renaissance Technologies LLC | 63,111 | $124K | 0.0% | -21.7% | 0.434% | |
| 7/26/2024 | AlphaCentric Advisors LLC | 310,500 | $612K | 0.5% | -30.2% | 2.137% | |
| 5/20/2024 | Virtu Financial LLC | 16,199 | $50K | 0.0% | N/A | 0.112% | |
| 2/20/2024 | Eventide Asset Management LLC | 1,394,336 | $3.25M | 0.1% | N/A | 9.988% | |
| 2/15/2024 | Parkman Healthcare Partners LLC | 696,470 | $1.62M | 0.2% | N/A | 4.990% | |
| 5/15/2023 | DSC Advisors L.P. | 115,000 | $354K | 0.3% | -92.7% | 3.523% | |
| 5/10/2023 | Staley Capital Advisers Inc. | 23,472 | $72K | 0.0% | -62.4% | 0.720% | |
| 10/7/2022 | Mackenzie Financial Corp | 134,920 | $30K | 0.0% | +106.8% | 0.233% | |
| 4/25/2022 | Bailard Inc. | 139,381 | $91K | 0.0% | N/A | 0.248% | |
| 2/15/2022 | DSC Advisors L.P. | 2,551,000 | $2.60M | 2.0% | +131.9% | 4.767% | |
| 2/14/2022 | Perceptive Advisors LLC | 2,178,022 | $2.22M | 0.0% | -6.5% | 4.070% | |
| 2/14/2022 | GSA Capital Partners LLP | 217,747 | $222K | 0.0% | +135.7% | 0.407% | |
| 1/24/2022 | SkyOak Wealth LLC | 27,200 | $28K | 0.0% | N/A | 0.051% | |
| 12/3/2021 | Perceptive Advisors LLC | 2,330,471 | $3.24M | 0.0% | -59.6% | 4.355% | |
| 11/16/2021 | Thrivent Financial for Lutherans | 71,990 | $101K | 0.0% | +20.2% | 0.140% | |
| 11/15/2021 | 683 Capital Management LLC | 715,386 | $994K | 0.0% | -2.5% | 1.389% | |
| 11/15/2021 | Healthcare Value Capital LLC | 400,000 | $556K | 1.1% | -11.1% | 0.777% | |
| 11/15/2021 | Franklin Resources Inc. | 1,921,236 | $2.67M | 0.0% | +1.1% | 3.730% | |
| 11/15/2021 | GSA Capital Partners LLP | 92,402 | $128K | 0.0% | N/A | 0.179% | |
| 11/12/2021 | Renaissance Technologies LLC | 1,245,027 | $1.73M | 0.0% | +300.4% | 2.417% | |
| 11/5/2021 | Staley Capital Advisers Inc. | 50,000 | $70K | 0.0% | +33.3% | 0.097% | |
| 10/29/2021 | Banque Cantonale Vaudoise | 80,000 | $111K | 0.0% | -60.0% | 0.155% | |
| 10/13/2021 | Deltec Asset Management LLC | 30,000 | $42K | 0.0% | -92.2% | 0.058% | |
| 9/24/2021 | Thrivent Financial for Lutherans | 59,884 | $211K | 0.0% | N/A | 0.116% | |
| 8/19/2021 | Thrivent Financial for Lutherans | 59,884 | $211K | 0.0% | N/A | 0.116% | |
| 8/17/2021 | Millennium Management LLC | 679,211 | $2.38M | 0.0% | +2,513.0% | 1.322% | |
| 8/17/2021 | Price T Rowe Associates Inc. MD | 40,050 | $141K | 0.0% | +23.5% | 0.078% | |
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| 8/17/2021 | 683 Capital Management LLC | 733,683 | $2.58M | 0.1% | N/A | 1.428% | |
| 8/16/2021 | LMR Partners LLP | 19,758 | $69K | 0.0% | N/A | 0.038% | |
| 8/16/2021 | Cubist Systematic Strategies LLC | 121,419 | $426K | 0.0% | N/A | 0.236% | |
| 8/16/2021 | Perceptive Advisors LLC | 5,773,954 | $20.27M | 0.2% | -14.8% | 11.236% | |
| 8/16/2021 | Charles Schwab Investment Management Inc. | 20,154 | $71K | 0.0% | -79.6% | 0.039% | |
| 8/16/2021 | State Street Corp | 534,613 | $1.88M | 0.0% | -44.3% | 1.040% | |
| 8/16/2021 | Tibra Equities Europe Ltd | 91,000 | $319K | 0.1% | N/A | 0.177% | |
| 8/13/2021 | Renaissance Technologies LLC | 310,927 | $1.09M | 0.0% | N/A | 0.605% | |
| 8/13/2021 | Northern Trust Corp | 98,524 | $346K | 0.0% | -74.9% | 0.192% | |
| 8/13/2021 | Franklin Resources Inc. | 1,900,863 | $6.67M | 0.0% | +12.5% | 3.699% | |
| 8/13/2021 | AXA S.A. | 120,644 | $423K | 0.0% | -86.3% | 0.235% | |
| 8/13/2021 | Geode Capital Management LLC | 466,599 | $1.64M | 0.0% | -36.0% | 0.908% | |
| 8/13/2021 | Vanguard Group Inc. | 2,436,432 | $8.55M | 0.0% | -2.1% | 4.741% | |
| 8/12/2021 | JPMorgan Chase & Co. | 11,008 | $38K | 0.0% | -85.9% | 0.021% | |
| 8/12/2021 | Ergoteles LLC | 158,800 | $557K | 0.0% | N/A | 0.309% | |
| 8/12/2021 | Connor Clark & Lunn Investment Management Ltd. | 60,186 | $211K | 0.0% | N/A | 0.117% | |
| 8/11/2021 | Bank of New York Mellon Corp | 26,626 | $94K | 0.0% | -81.4% | 0.052% | |
| 8/11/2021 | BlackRock Inc. | 1,037,677 | $3.64M | 0.0% | -71.2% | 2.019% | |
| 8/11/2021 | Deutsche Bank AG | 48,234 | $169K | 0.0% | +104.2% | 0.094% | |
| 8/11/2021 | Banque Cantonale Vaudoise | 200,000 | $702K | 0.0% | N/A | 0.389% | |
| 8/10/2021 | Principal Financial Group Inc. | 11,849 | $42K | 0.0% | N/A | 0.023% | |
| 8/9/2021 | Staley Capital Advisers Inc. | 37,500 | $132K | 0.0% | +50.0% | 0.073% | |
| 8/6/2021 | HighTower Advisors LLC | 13,504 | $50K | 0.0% | -44.3% | 0.026% | |
| 8/5/2021 | Platform Technology Partners | 15,832 | $56K | 0.0% | N/A | 0.031% | |
| 8/5/2021 | Fernwood Investment Management LLC | 10,802 | $38K | 0.0% | -29.4% | 0.021% | |
| 5/20/2021 | Axiom Investment Management LLC | 14,297 | $101K | 0.0% | N/A | 0.028% | |
| 5/19/2021 | Virtu Financial LLC | 13,598 | $93K | 0.0% | -79.5% | 0.026% | |
| 5/19/2021 | Squarepoint Ops LLC | 17,583 | $120K | 0.0% | -96.8% | 0.034% | |
| 5/18/2021 | Millennium Management LLC | 25,994 | $178K | 0.0% | N/A | 0.051% | |
| 5/18/2021 | Highland Capital Management Fund Advisors L.P. | 10,051 | $69K | 0.0% | -75.0% | 0.020% | |
| 5/18/2021 | State of Wisconsin Investment Board | 50,898 | $348K | 0.0% | -75.0% | 0.099% | |
| 5/18/2021 | Jane Street Group LLC | 16,829 | $115K | 0.0% | N/A | 0.033% | |
| 5/18/2021 | California State Teachers Retirement System | 54,938 | $376K | 0.0% | -75.0% | 0.107% | |
| 5/18/2021 | Beacon Pointe Advisors LLC | 12,243 | $83K | 0.0% | -72.9% | 0.024% | |
| 5/17/2021 | Vivo Capital LLC | 234,877 | $1.61M | 0.1% | -75.0% | 0.457% | |
| 5/17/2021 | Schonfeld Strategic Advisors LLC | 17,450 | $119K | 0.0% | -76.7% | 0.034% | |
| 5/17/2021 | Perceptive Advisors LLC | 6,773,954 | $46.37M | 0.6% | -70.4% | 13.182% | |
| 5/17/2021 | CSS LLC IL | 25,264 | $173K | 0.0% | -78.2% | 0.049% | |
| 5/17/2021 | Price T Rowe Associates Inc. MD | 32,441 | $222K | 0.0% | N/A | 0.063% | |
| 5/17/2021 | Ameriprise Financial Inc. | 32,078 | $220K | 0.0% | -83.2% | 0.062% | |
| 5/17/2021 | Nuveen Asset Management LLC | 146,946 | $1.01M | 0.0% | -76.2% | 0.286% | |
| 5/17/2021 | Healthcare Value Capital LLC | 400,000 | $2.74M | 6.1% | -80.0% | 0.778% | |
| 5/17/2021 | Goldman Sachs Group Inc. | 45,271 | $310K | 0.0% | -74.2% | 0.088% | |
| 5/14/2021 | First Manhattan Co. | 5,329 | $36K | 0.0% | -75.0% | 0.010% | |
| 5/14/2021 | Tekla Capital Management LLC | 135,395 | $927K | 0.0% | -75.0% | 0.263% | |
| 5/14/2021 | BDO Wealth Advisors LLC | 5,000 | $34K | 0.0% | -75.0% | 0.010% | |
| 5/13/2021 | Franklin Resources Inc. | 1,689,263 | $11.56M | 0.0% | -75.0% | 3.287% | |
| 5/13/2021 | Axiom Investment Management LLC | 14,297 | $101K | 0.0% | N/A | 0.028% | |
| 5/13/2021 | Bank of New York Mellon Corp | 142,968 | $979K | 0.0% | -74.0% | 0.278% | |
| 5/13/2021 | Citigroup Inc. | 149,164 | $1.02M | 0.0% | +356.8% | 0.290% | |
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| 5/12/2021 | Northern Trust Corp | 393,272 | $2.69M | 0.0% | -74.5% | 0.765% | |
| 5/12/2021 | Geode Capital Management LLC | 729,623 | $4.99M | 0.0% | -68.4% | 1.420% | |
| 5/12/2021 | CM Management LLC | 143,750 | $984K | 0.7% | -77.7% | 0.280% | |
| 5/12/2021 | JPMorgan Chase & Co. | 77,832 | $533K | 0.0% | -86.8% | 0.151% | |
| 5/12/2021 | UBS Group AG | 6,657 | $46K | 0.0% | -95.5% | 0.013% | |
| 5/11/2021 | New York State Common Retirement Fund | 24,349 | $167K | 0.0% | -75.0% | 0.047% | |
| 5/10/2021 | HighTower Advisors LLC | 24,228 | $165K | 0.0% | N/A | 0.047% | |
| 5/10/2021 | State Board of Administration of Florida Retirement System | 12,564 | $86K | 0.0% | -75.0% | 0.024% | |
| 5/7/2021 | BlackRock Inc. | 3,606,773 | $24.69M | 0.0% | -69.9% | 7.019% | |
| 5/7/2021 | American International Group Inc. | 21,157 | $145K | 0.0% | -74.9% | 0.041% | |
