| 2/18/2025 | Knoll Capital Management LLC | 5,799,687 | $4.97M | 3.2% | +4.0% | 4.984% | |
| 2/17/2025 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 119,035 | $102K | 0.0% | N/A | 0.102% | |
| 2/17/2025 | VR Adviser LLC | 9,990,591 | $8.55M | 0.6% | +1.7% | 8.586% | |
| 2/17/2025 | Windsor Advisory Group LLC | 416,757 | $357K | 0.4% | +109.4% | 0.358% | |
| 2/17/2025 | Vestal Point Capital LP | 11,500,000 | $9.85M | 0.6% | +904.4% | 9.883% | |
| 2/17/2025 | Two Sigma Investments LP | 293,810 | $252K | 0.0% | N/A | 0.253% | |
| 2/17/2025 | Tang Capital Management LLC | 2,428,169 | $2.08M | 0.1% | -11.1% | 2.087% | |
| 2/17/2025 | Toronto Dominion Bank | 32,000 | $27K | 0.0% | N/A | 0.028% | |
| 2/17/2025 | Sphera Funds Management LTD. | 50,000 | $43K | 0.0% | -84.0% | 0.043% | |
| 2/17/2025 | Nuveen Asset Management LLC | 281,028 | $241K | 0.0% | +7.5% | 0.242% | |
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| 2/17/2025 | Millennium Management LLC | 1,329,149 | $1.14M | 0.0% | +252.2% | 1.142% | |
| 2/17/2025 | Janus Henderson Group PLC | 35,791 | $31K | 0.0% | -99.7% | 0.031% | |
| 2/17/2025 | Jefferies Financial Group Inc. | 276,700 | $237K | 0.0% | N/A | 0.238% | |
| 2/17/2025 | Ground Swell Capital LLC | 31,636 | $27K | 0.0% | N/A | 0.027% | |
| 2/17/2025 | Deutsche Bank AG | 4,468,122 | $3.84M | 0.0% | +0.7% | 3.840% | |
| 2/17/2025 | Bank of America Corp DE | 167,415 | $143K | 0.0% | -46.8% | 0.144% | |
| 2/17/2025 | BNP Paribas Financial Markets | 174,651 | $150K | 0.0% | +29.1% | 0.150% | |
| 2/17/2025 | Alyeska Investment Group L.P. | 2,707,497 | $2.32M | 0.0% | +175.8% | 2.327% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 8,762,291 | $7.50M | 0.0% | +2,458.3% | 7.530% | |
| 2/14/2025 | Tudor Investment Corp ET AL | 57,454 | $49K | 0.0% | N/A | 0.049% | |
| 2/14/2025 | Propel Bio Management LLC | 9,615,420 | $8.23M | 8.2% | +46.4% | 8.264% | |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 1,961,629 | $1.68M | 0.0% | -52.3% | 1.686% | |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 34,763 | $30K | 0.0% | -96.6% | 0.030% | |
| 2/14/2025 | T. Rowe Price Investment Management Inc. | 5,420,920 | $4.64M | 0.0% | +2,511.9% | 4.659% | |
| 2/14/2025 | Dark Forest Capital Management LP | 53,718 | $46K | 0.0% | +54.5% | 0.046% | |
| 2/14/2025 | Rock Springs Capital Management LP | 1,917,191 | $1.64M | 0.1% | +9.8% | 1.648% | |
| 2/13/2025 | Marshall Wace LLP | 1,307,381 | $1.12M | 0.0% | +144.8% | 1.124% | |
| 2/13/2025 | XTX Topco Ltd | 173,568 | $149K | 0.0% | +178.0% | 0.149% | |
| 2/13/2025 | Barclays PLC | 172,015 | $147K | 0.0% | -14.0% | 0.148% | |
| 2/13/2025 | Legal & General Group Plc | 84,018 | $72K | 0.0% | +293.9% | 0.072% | |
| 2/13/2025 | Invesco Ltd. | 53,499 | $46K | 0.0% | -90.4% | 0.046% | |
| 2/13/2025 | Aristides Capital LLC | 156,507 | $134K | 0.0% | N/A | 0.135% | |
| 2/12/2025 | Franklin Resources Inc. | 2,003,400 | $1.72M | 0.0% | -70.5% | 1.722% | |
| 2/12/2025 | Wellington Management Group LLP | 237,850 | $204K | 0.0% | +17.8% | 0.204% | |
| 2/12/2025 | Norges Bank | 243,200 | $208K | 0.0% | N/A | 0.209% | |
| 2/11/2025 | Intech Investment Management LLC | 52,631 | $45K | 0.0% | +176.1% | 0.045% | |
| 2/10/2025 | Swiss National Bank | 146,900 | $126K | 0.0% | N/A | 0.126% | |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 700,836 | $600K | 0.0% | -4.7% | 0.602% | |
| 2/3/2025 | Private Advisor Group LLC | 40,300 | $35K | 0.0% | N/A | 0.035% | |
| 1/17/2025 | SG Americas Securities LLC | 40,747 | $35K | 0.0% | +169.0% | 0.035% | |
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| 1/15/2025 | Hennion & Walsh Asset Management Inc. | 313,355 | $268K | 0.0% | +18.1% | 0.269% | |
| 11/27/2024 | Franklin Resources Inc. | 6,800,910 | $60.46M | 0.0% | -33.4% | 5.845% | |
| 11/19/2024 | Barclays PLC | 200,012 | $1.70M | 0.0% | +186.1% | 0.172% | |
| 11/16/2024 | Geode Capital Management LLC | 2,091,669 | $17.78M | 0.0% | -0.3% | 1.798% | |
| 11/15/2024 | Barclays PLC | 200,012 | $1.70M | 0.0% | +186.1% | 0.172% | |
| 11/15/2024 | Y Intercept Hong Kong Ltd | 17,542 | $149K | 0.0% | N/A | 0.015% | |
| 11/15/2024 | XTX Topco Ltd | 62,440 | $531K | 0.0% | N/A | 0.054% | |
| 11/15/2024 | Wellington Management Group LLP | 201,966 | $1.72M | 0.0% | N/A | 0.174% | |
| 11/15/2024 | Sphera Funds Management LTD. | 311,572 | $2.65M | 0.4% | -53.8% | 0.268% | |
| 11/15/2024 | State Street Corp | 3,694,607 | $31.40M | 0.0% | +123.1% | 3.175% | |
| 11/15/2024 | Parkman Healthcare Partners LLC | 907,294 | $7.71M | 1.0% | -21.0% | 0.780% | |
| 11/15/2024 | Janus Henderson Group PLC | 10,541,528 | $89.66M | 0.0% | +37.8% | 9.059% | |
| 11/14/2024 | Vestal Point Capital LP | 1,145,000 | $9.73M | 0.7% | -78.9% | 0.984% | |
| 11/14/2024 | Walleye Capital LLC | 137,593 | $1.17M | 0.0% | -65.8% | 0.118% | |
| 11/14/2024 | Ally Bridge Group NY LLC | 618,332 | $5.26M | 2.8% | N/A | 0.531% | |
| 11/14/2024 | MetLife Investment Management LLC | 56,302 | $479K | 0.0% | +129.1% | 0.048% | |
| 11/13/2024 | BNP Paribas Financial Markets | 135,272 | $1.15M | 0.0% | +1,855.1% | 0.116% | |
| 11/13/2024 | The Manufacturers Life Insurance Company | 123,725 | $1.05M | 0.0% | +236.0% | 0.106% | |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 735,217 | $6.25M | 0.0% | +165.2% | 0.640% | |
| 11/9/2024 | Intech Investment Management LLC | 19,064 | $162K | 0.0% | N/A | 0.017% | |
| 10/23/2024 | Hennion & Walsh Asset Management Inc. | 265,372 | $2.26M | 0.1% | +34.7% | 0.232% | |
| 10/3/2024 | SG Americas Securities LLC | 15,146 | $129K | 0.0% | -18.4% | 0.013% | |
| 8/27/2024 | Logos Global Management LP | 600,000 | $2.66M | 0.2% | -55.6% | 0.525% | |
| 8/16/2024 | Perceptive Advisors LLC | 8,005,000 | $37.38M | 0.9% | -5.9% | 7.006% | |
| 8/16/2024 | Algert Global LLC | 23,476 | $110K | 0.0% | N/A | 0.021% | |
| 8/16/2024 | Frazier Life Sciences Management L.P. | 2,286,135 | $10.68M | 0.5% | +17.1% | 2.001% | |
| 8/15/2024 | The Manufacturers Life Insurance Company | 36,824 | $172K | 0.0% | N/A | 0.032% | |
| 8/14/2024 | Logos Global Management LP | 600,000 | $2.66M | 0.2% | -55.6% | 0.525% | |
| 8/13/2024 | Sei Investments Co. | 114,619 | $535K | 0.0% | N/A | 0.100% | |
| 8/12/2024 | Marathon Trading Investment Management LLC | 15,907 | $74K | 0.0% | -73.0% | 0.014% | |
| 8/5/2024 | Victory Capital Management Inc. | 11,494 | $54K | 0.0% | N/A | 0.010% | |
| 8/1/2024 | Rhumbline Advisers | 133,895 | $625K | 0.0% | +24,513.1% | 0.117% | |
| 7/29/2024 | Peregrine Capital Management LLC | 731,048 | $3.41M | 0.1% | N/A | 0.640% | |
| 7/29/2024 | Principal Financial Group Inc. | 11,583 | $54K | 0.0% | N/A | 0.010% | |
| 7/26/2024 | Bank of New York Mellon Corp | 283,793 | $1.33M | 0.0% | N/A | 0.248% | |
| 7/20/2024 | Hennion & Walsh Asset Management Inc. | 197,042 | $920K | 0.0% | N/A | 0.172% | |
| 7/12/2024 | SG Americas Securities LLC | 18,567 | $87K | 0.0% | N/A | 0.016% | |
| 5/29/2024 | Opaleye Management Inc. | 1,770,000 | $12.04M | 2.6% | +62.0% | 1.549% | |
| 5/17/2024 | Artal Group S.A. | 1,009,500 | $6.87M | 0.2% | N/A | 0.883% | |
| 5/16/2024 | Janus Henderson Group PLC | 6,414,642 | $43.56M | 0.0% | +198.6% | 5.614% | |
| 5/16/2024 | Knoll Capital Management LLC | 5,574,687 | $37.91M | 23.6% | +1.8% | 4.879% | |
| 5/15/2024 | Altitude Crest Partners Inc. | 259,700 | $1.77M | 0.8% | N/A | 0.227% | |
| 5/14/2024 | EntryPoint Capital LLC | 40,070 | $272K | 0.2% | N/A | 0.035% | |
| 5/14/2024 | StemPoint Capital LP | 2,017,016 | $13.72M | 3.6% | +122.3% | 1.765% | |
| 5/14/2024 | Propel Bio Management LLC | 6,111,906 | $41.56M | 23.1% | +13.7% | 5.349% | |
| 5/10/2024 | Vanguard Group Inc. | 3,010,290 | $20.47M | 0.0% | -6.8% | 2.635% | |
| 5/10/2024 | Richmond Brothers Inc. | 61,827 | $420K | 0.8% | -50.0% | 0.054% | |
| 5/7/2024 | Susquehanna Portfolio Strategies LLC | 14,099 | $96K | 0.0% | -43.8% | 0.012% | |
| 4/19/2024 | Denali Advisors LLC | 33,600 | $228K | 0.1% | N/A | 0.032% | |
| 2/15/2024 | Opaleye Management Inc. | 1,092,500 | $3.66M | 1.0% | +22.3% | 1.415% | |
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| 2/15/2024 | Parkman Healthcare Partners LLC | 1,019,156 | $3.41M | 0.5% | -41.8% | 1.320% | |
| 2/14/2024 | Vestal Point Capital LP | 4,155,000 | $13.92M | 1.5% | N/A | 5.380% | |
| 2/13/2024 | Tower Research Capital LLC TRC | 23,175 | $78K | 0.0% | -34.6% | 0.030% | |
| 2/12/2024 | AIGH Capital Management LLC | 1,659,039 | $5.56M | 2.2% | +109.1% | 2.148% | |
| 2/9/2024 | Worth Venture Partners LLC | 412,981 | $1.38M | 0.7% | +112.9% | 0.535% | |
| 2/9/2024 | Franklin Resources Inc. | 7,017,912 | $23.51M | 0.0% | -11.7% | 9.087% | |
| 2/7/2024 | Jump Financial LLC | 24,171 | $81K | 0.0% | N/A | 0.031% | |
| 1/30/2024 | Vontobel Holding Ltd. | 10,000 | $34K | 0.0% | N/A | 0.013% | |
| 12/6/2023 | Citigroup Inc. | 65,976 | $164K | 0.0% | N/A | 0.085% | |
| 11/15/2023 | Worth Venture Partners LLC | 193,973 | $483K | 0.3% | N/A | 0.251% | |
