Karyopharm Therapeutics (KPTI) Stock Chart & Stock Price History $7.11 -0.57 (-7.42%) Closing price 08/29/2025 04:00 PM EasternExtended Trading$7.09 -0.02 (-0.34%) As of 08/29/2025 07:22 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Karyopharm Therapeutics Stock Price Performance The Karyopharm Therapeutics (KPTI) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 37.65%, with a year-to-date return of -29.91%. In the past month, the stock has increased 75.56%, reflecting recent market activity. As of the latest close, Karyopharm Therapeutics traded at $7.11 with a market cap of $61.64 million and volume of 132,469 shares. Five years ago, the stock traded at a split-adjusted price of $221.85, representing a 96.80% decrease over that period. At the time, it had a market cap of $1.07 billion and a volume of 101,274 shares. Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. 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Read our full terms of service and privacy policy. 5 Day Performance+12.68%1 Month Performance+75.56%3 Month Performance+65.35%Year-To-Date Performance-29.91%1 Year Performance-37.65%5 Year Performance-96.80% KPTI Stock Chart for Saturday, August, 30, 2025 KPTI Chart by TradingView Karyopharm Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization08/29/2025$7.68$7.11-7.42%$7.72$7.07132,469 shs$61.64 million08/28/2025$7.81$7.68-1.66%$8.06$7.6072,413 shs$66.59 million08/27/2025$7.46$7.81+4.69%$8.15$7.43183,458 shs$67.71 million08/26/2025$6.31$7.46+18.23%$7.50$6.21177,722 shs$64.68 million08/25/2025$6.30$6.31+0.16%$6.42$6.1064,845 shs$54.71 million08/22/2025$6.02$6.30+4.65%$6.52$6.03112,192 shs$54.63 million08/21/2025$6.50$6.02-7.38%$6.68$6.0288,331 shs$52.19 million08/20/2025$6.22$6.50+4.50%$7.01$6.14313,071 shs$56.36 million08/19/2025$5.59$6.22+11.27%$6.40$5.49135,787 shs$53.93 million08/18/2025$5.92$5.59-5.57%$5.89$5.50124,675 shs$48.47 million Get the Latest News and Ratings for KPTI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 08/15/2025$4.65$5.92+27.31%$6.90$4.671.62 million shs$51.33 million08/14/2025$4.45$4.65+4.49%$4.72$4.31154,872 shs$40.32 million08/13/2025$4.02$4.45+10.70%$4.60$4.01144,585 shs$38.45 million08/12/2025$3.77$4.02+6.63%$4.16$3.74183,556 shs$34.73 million08/11/2025$3.94$3.77-4.31%$4.01$3.65301,151 shs$32.57 million08/08/2025$3.97$3.94-0.76%$4.07$3.8390,784 shs$34.04 million08/07/2025$4.03$3.97-1.49%$4.35$3.87211,424 shs$34.30 million08/06/2025$3.88$4.03+3.87%$4.15$3.81103,916 shs$34.82 million08/05/2025$4.02$3.88-3.48%$4.17$3.85108,931 shs$33.52 million08/04/2025$3.93$4.02+2.29%$4.08$3.8328,589 shs$34.73 million08/01/2025$3.81$3.93+3.15%$4.04$3.7164,132 shs$33.96 million07/31/2025$4.05$3.81-5.93%$4.09$3.75116,504 shs$32.92 million07/30/2025$4.13$4.05-1.94%$4.36$4.0043,722 shs$34.99 million07/29/2025$4.37$4.13-5.49%$4.39$4.0086,560 shs$35.68 million Related Companies CARGO Therapeutics Stock Chart AC Immune Stock Chart Heron Therapeutics Stock Chart Organigram Global Stock Chart Aardvark Therapeutics Stock Chart Innate Pharma Stock Chart Lyell Immunopharma Stock Chart Cognition Therapeutics Stock Chart SELLAS Life Sciences Group Stock Chart Monopar Therapeutics Stock Chart Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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