| 2/18/2025 | Frazier Life Sciences Management L.P. | 3,175,665 | $10.32M | 0.4% | +5.5% | 5.060% | |
| 2/17/2025 | Vestal Point Capital LP | 280,000 | $910K | 0.1% | -66.3% | 0.446% | |
| 2/17/2025 | Two Sigma Advisers LP | 1,118,600 | $3.64M | 0.0% | +7.1% | 1.782% | |
| 2/17/2025 | Two Sigma Investments LP | 860,745 | $2.80M | 0.0% | -2.6% | 1.371% | |
| 2/17/2025 | ProShare Advisors LLC | 20,284 | $66K | 0.0% | +32.4% | 0.032% | |
| 2/17/2025 | Millennium Management LLC | 2,864,721 | $9.31M | 0.0% | -19.0% | 4.565% | |
| 2/17/2025 | Lazard Asset Management LLC | 9,869 | $32K | 0.0% | N/A | 0.016% | |
| 2/17/2025 | Cubist Systematic Strategies LLC | 111,993 | $364K | 0.0% | N/A | 0.178% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 104,000 | $338K | 0.0% | N/A | 0.166% | |
| 2/17/2025 | Bank of America Corp DE | 201,151 | $654K | 0.0% | +41.5% | 0.321% | |
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| 2/17/2025 | Ameriprise Financial Inc. | 54,334 | $177K | 0.0% | -32.8% | 0.087% | |
| 2/14/2025 | PDT Partners LLC | 27,389 | $89K | 0.0% | -82.9% | 0.044% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 857,505 | $2.79M | 0.0% | N/A | 1.366% | |
| 2/14/2025 | Northern Trust Corp | 540,970 | $1.76M | 0.0% | -23.0% | 0.862% | |
| 2/14/2025 | Tudor Investment Corp ET AL | 10,950 | $36K | 0.0% | -64.9% | 0.017% | |
| 2/14/2025 | Oxford Asset Management LLP | 27,410 | $89K | 0.0% | N/A | 0.044% | |
| 2/14/2025 | Susquehanna Fundamental Investments LLC | 89,134 | $290K | 0.0% | N/A | 0.142% | |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 485,987 | $1.58M | 0.0% | -61.3% | 0.774% | |
| 2/14/2025 | Stifel Financial Corp | 25,861 | $84K | 0.0% | -35.2% | 0.041% | |
| 2/14/2025 | MetLife Investment Management LLC | 39,669 | $129K | 0.0% | +162.8% | 0.063% | |
| 2/14/2025 | Dimensional Fund Advisors LP | 717,288 | $2.33M | 0.0% | -18.7% | 1.143% | |
| 2/13/2025 | Marshall Wace LLP | 393,766 | $1.28M | 0.0% | +3.2% | 0.627% | |
| 2/13/2025 | Wasatch Advisors LP | 3,488,493 | $11.34M | 0.1% | +37.6% | 5.558% | |
| 2/13/2025 | Jump Financial LLC | 13,600 | $44K | 0.0% | N/A | 0.022% | |
| 2/13/2025 | Walleye Capital LLC | 38,353 | $125K | 0.0% | -66.6% | 0.061% | |
| 2/13/2025 | XTX Topco Ltd | 66,742 | $217K | 0.0% | +497.1% | 0.106% | |
| 2/13/2025 | Barclays PLC | 111,891 | $363K | 0.0% | +13.3% | 0.178% | |
| 2/13/2025 | Renaissance Technologies LLC | 538,523 | $1.75M | 0.0% | +69.1% | 0.858% | |
| 2/13/2025 | Wells Fargo & Company MN | 29,838 | $97K | 0.0% | +45.4% | 0.048% | |
| 2/12/2025 | Geode Capital Management LLC | 1,433,217 | $4.66M | 0.0% | +1.9% | 2.284% | |
| 2/12/2025 | Wellington Management Group LLP | 323,857 | $1.05M | 0.0% | +5.4% | 0.516% | |
| 2/12/2025 | JPMorgan Chase & Co. | 546,807 | $1.78M | 0.0% | +68.3% | 0.871% | |
| 2/11/2025 | LPL Financial LLC | 21,158 | $69K | 0.0% | -28.7% | 0.034% | |
| 2/11/2025 | American Century Companies Inc. | 11,743 | $38K | 0.0% | N/A | 0.019% | |
| 2/11/2025 | Kazazian Asset Management LLC | 42,036 | $137K | 0.1% | N/A | 0.067% | |
| 2/10/2025 | Connor Clark & Lunn Investment Management Ltd. | 744,902 | $2.42M | 0.0% | +12.5% | 1.187% | |
| 2/6/2025 | SPC Financial Inc. | 37,750 | $123K | 0.0% | N/A | 0.060% | |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 527,185 | $1.71M | 0.0% | +7.0% | 0.840% | |
| 2/4/2025 | Bank of New York Mellon Corp | 166,122 | $540K | 0.0% | -24.0% | 0.265% | |
| 1/17/2025 | SG Americas Securities LLC | 34,399 | $112K | 0.0% | +104.5% | 0.055% | |
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| 1/17/2025 | XML Financial LLC | 23,169 | $75K | 0.0% | +31.6% | 0.037% | |
| 1/15/2025 | Sanders Morris Harris LLC | 12,345 | $40K | 0.0% | N/A | 0.020% | |
| 12/26/2024 | JPMorgan Chase & Co. | 324,902 | $1.07M | 0.0% | -32.3% | 0.518% | |
| 11/19/2024 | Barclays PLC | 98,753 | $325K | 0.0% | +97.1% | 0.157% | |
| 11/16/2024 | Geode Capital Management LLC | 1,406,876 | $4.63M | 0.0% | -0.6% | 2.242% | |
| 11/15/2024 | Barclays PLC | 98,753 | $325K | 0.0% | +97.1% | 0.157% | |
| 11/15/2024 | XTX Topco Ltd | 11,178 | $37K | 0.0% | N/A | 0.018% | |
| 11/15/2024 | Wellington Management Group LLP | 307,140 | $1.01M | 0.0% | +15.7% | 0.489% | |
| 11/15/2024 | State Street Corp | 1,427,390 | $4.70M | 0.0% | -7.5% | 2.274% | |
| 11/15/2024 | Stifel Financial Corp | 39,888 | $131K | 0.0% | +19.7% | 0.064% | |
| 11/15/2024 | Ikarian Capital LLC | 80,079 | $263K | 0.0% | -60.0% | 0.128% | |
| 11/15/2024 | Jacobs Levy Equity Management Inc. | 566,328 | $1.86M | 0.0% | +35.2% | 0.902% | |
| 11/14/2024 | Bellevue Group AG | 9,929,963 | $32.67M | 0.5% | -0.1% | 15.822% | |
| 11/14/2024 | Wasatch Advisors LP | 2,535,802 | $8.34M | 0.0% | +3.4% | 4.040% | |
| 11/14/2024 | PDT Partners LLC | 160,039 | $527K | 0.0% | +44.5% | 0.255% | |
| 11/14/2024 | Verition Fund Management LLC | 90,304 | $297K | 0.0% | N/A | 0.144% | |
| 11/14/2024 | Vestal Point Capital LP | 830,000 | $2.73M | 0.2% | +3.8% | 1.322% | |
| 11/14/2024 | Walleye Capital LLC | 114,744 | $378K | 0.0% | -43.7% | 0.183% | |
| 11/14/2024 | MetLife Investment Management LLC | 15,093 | $50K | 0.0% | -57.5% | 0.024% | |
| 11/13/2024 | BNP Paribas Financial Markets | 90,779 | $299K | 0.0% | +374.4% | 0.145% | |
| 11/13/2024 | FMR LLC | 137,215 | $451K | 0.0% | +1,230.1% | 0.219% | |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 492,765 | $1.62M | 0.0% | -3.5% | 0.785% | |
| 11/9/2024 | Intech Investment Management LLC | 20,763 | $68K | 0.0% | N/A | 0.033% | |
| 11/8/2024 | Connor Clark & Lunn Investment Management Ltd. | 661,914 | $2.18M | 0.0% | +39.3% | 1.055% | |
| 11/5/2024 | GSA Capital Partners LLP | 207,877 | $684K | 0.1% | +117.2% | 0.331% | |
| 11/2/2024 | XML Financial LLC | 17,600 | $58K | 0.0% | +66.0% | 0.028% | |
| 10/25/2024 | Pinnacle Associates Ltd. | 687,980 | $2.26M | 0.0% | +7.9% | 1.097% | |
| 10/25/2024 | China Universal Asset Management Co. Ltd. | 12,064 | $40K | 0.0% | +64.0% | 0.019% | |
| 10/10/2024 | Exchange Traded Concepts LLC | 48,823 | $161K | 0.0% | +260.8% | 0.078% | |
| 10/3/2024 | SG Americas Securities LLC | 16,822 | $55K | 0.0% | N/A | 0.027% | |
| 8/16/2024 | Frazier Life Sciences Management L.P. | 3,010,727 | $12.80M | 0.6% | +21.8% | 4.807% | |
| 8/15/2024 | Susquehanna Fundamental Investments LLC | 129,996 | $552K | 0.0% | +22.9% | 0.208% | |
| 8/15/2024 | Millennium Management LLC | 3,312,672 | $14.08M | 0.0% | +3,473.7% | 5.289% | |
| 8/15/2024 | AQR Capital Management LLC | 143,161 | $608K | 0.0% | +74.5% | 0.229% | |
| 8/15/2024 | Armistice Capital LLC | 6,000,000 | $25.50M | 0.3% | +150.0% | 9.580% | |
| 8/14/2024 | K2 Principal Fund L.P. | 14,800 | $63K | 0.0% | N/A | 0.024% | |
| 8/14/2024 | Marshall Wace LLP | 658,007 | $2.80M | 0.0% | +1,689.3% | 1.051% | |
| 8/14/2024 | DRW Securities LLC | 13,105 | $56K | 0.0% | N/A | 0.021% | |
| 8/14/2024 | ProShare Advisors LLC | 12,018 | $51K | 0.0% | -21.4% | 0.019% | |
| 8/12/2024 | Hsbc Holdings PLC | 12,103 | $50K | 0.0% | -27.7% | 0.019% | |
| 8/9/2024 | Renaissance Technologies LLC | 484,027 | $2.06M | 0.0% | -32.3% | 0.773% | |
| 8/9/2024 | Dimensional Fund Advisors LP | 898,497 | $3.82M | 0.0% | -14.5% | 1.435% | |
| 8/8/2024 | Federated Hermes Inc. | 300,499 | $1.28M | 0.0% | -33.8% | 0.480% | |
| 8/6/2024 | Acadian Asset Management LLC | 586,079 | $2.49M | 0.0% | +23.8% | 0.936% | |
| 8/3/2024 | TD Asset Management Inc | 169,000 | $718K | 0.0% | -20.8% | 0.270% | |
| 8/1/2024 | Rhumbline Advisers | 88,294 | $375K | 0.0% | -5.2% | 0.141% | |
| 7/30/2024 | Pinnacle Associates Ltd. | 637,319 | $2.71M | 0.0% | -1.5% | 1.018% | |
| 7/29/2024 | Principal Financial Group Inc. | 348,421 | $1.48M | 0.0% | +1.1% | 0.556% | |
| 7/29/2024 | Panagora Asset Management Inc. | 741,490 | $3.15M | 0.0% | +60.0% | 1.184% | |
| 7/29/2024 | Zurcher Kantonalbank Zurich Cantonalbank | 16,072 | $68K | 0.0% | +300.6% | 0.026% | |
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| 7/26/2024 | Bank of New York Mellon Corp | 261,944 | $1.11M | 0.0% | +4.9% | 0.418% | |
| 7/16/2024 | Diversified Trust Co | 18,097 | $77K | 0.0% | +32.8% | 0.029% | |
| 5/17/2024 | RA Capital Management L.P. | 2,082,021 | $30.65M | 0.4% | -48.6% | 3.324% | |
| 5/16/2024 | California State Teachers Retirement System | 47,955 | $706K | 0.0% | +378.7% | 0.077% | |
| 5/16/2024 | Jacobs Levy Equity Management Inc. | 148,018 | $2.18M | 0.0% | +28.7% | 0.236% | |
| 5/16/2024 | Janus Henderson Group PLC | 33,403 | $492K | 0.0% | N/A | 0.053% | |
| 5/15/2024 | Bellevue Group AG | 9,965,862 | $146.70M | 2.2% | +0.1% | 15.912% | |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 2,438,050 | $35.89M | 0.0% | +8,361.6% | 3.893% | |
| 5/15/2024 | Avoro Capital Advisors LLC | 6,150,000 | $90.53M | 1.1% | N/A | 9.820% | |
| 5/14/2024 | EntryPoint Capital LLC | 2,695 | $40K | 0.0% | N/A | 0.004% | |
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