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Septerna (SEPN) Institutional Ownership

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$14.43 +0.31 (+2.20%)
Closing price 09/5/2025 04:00 PM Eastern
Extended Trading
$14.12 -0.32 (-2.18%)
As of 09/5/2025 06:49 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.
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Institutional Ownership Changes (13F Filings) for Septerna (NASDAQ:SEPN)

Number of
Institutional Buyers
(last 12 months)
66
Total
Institutional Inflows
(last 12 months)
$823.68M
Number of
Institutional Sellers
(last 12 months)
5
Total
Institutional Outflows
(last 12 months)
$10.89M
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SEPN Institutional Buying and Selling by Quarter

Septerna Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
8/15/2025 Soleus Capital Management L.P.75,456$798K0.1%-90.0%0.169%
8/15/2025 Rangeley Capital LLC58,605$619K0.8%+10.7%0.131%
8/15/2025 Perceptive Advisors LLC541,450$5.72M0.5%N/A1.215%
8/15/2025 Boothbay Fund Management LLC24,142$255K0.0%N/A0.054%
8/15/2025 Bank of America Corp DE99,213$1.05M0.0%+758.3%0.223%
8/14/2025 VR Adviser LLC540,453$5.71M0.4%N/A1.213%
8/13/2025 CW Advisors LLC12,589$133K0.0%N/A0.028%
8/13/2025 PharVision Advisers LLC10,152$107K0.2%N/A0.023%
8/13/2025 Sio Capital Management LLC584,435$6.18M2.4%-25.9%1.312%
8/13/2025 Quadrature Capital Ltd10,125$107K0.0%N/A0.023%
8/12/2025 XTX Topco Ltd22,330$236K0.0%-40.2%0.050%
8/12/2025 Rhumbline Advisers28,572$302K0.0%+22.5%0.064%
8/12/2025 JPMorgan Chase & Co.10,101$107K0.0%+15.0%0.023%
8/11/2025 Universal Beteiligungs und Servicegesellschaft mbH222,702$2.35M0.0%+116.7%0.500%
8/8/2025 Intech Investment Management LLC12,200$129K0.0%N/A0.027%
8/8/2025 Geode Capital Management LLC487,956$5.16M0.0%+19.1%1.095%
5/29/2025 Rhumbline Advisers23,318$135K0.0%+16.6%0.052%
5/16/2025 Woodline Partners LP582,585$3.37M0.0%+94.2%1.309%
5/16/2025 Goldman Sachs Group Inc.1,449,399$8.39M0.0%-13.4%3.253%
5/16/2025 Checkpoint Capital L.P.824,878$4.78M2.6%N/A1.853%
5/16/2025 BVF Inc. IL4,396,124$25.45M1.0%+79.3%9.875%
5/16/2025 ADAR1 Capital Management LLC720,848$4.17M0.8%N/A1.619%
5/15/2025 Driehaus Capital Management LLC3,122,608$18.08M0.2%+20.6%7.015%
5/14/2025 Stonepine Capital Management LLC68,084$394K0.4%N/A0.153%
5/14/2025 Stoneridge Investment Partners LLC18,477$107K0.1%N/A0.042%
5/12/2025 Nuveen LLC23,961$139K0.0%N/A0.054%
5/12/2025 Swiss National Bank30,100$174K0.0%N/A0.068%
5/9/2025 Deutsche Bank AG15,968$92K0.0%+53.3%0.036%
5/9/2025 TRV GP VI LLC4,211,659$24.39M58.1%+33.6%9.461%
5/9/2025 Chicago Partners Investment Group LLC10,954$63K0.0%N/A0.025%
5/9/2025 Charles Schwab Investment Management Inc.118,451$686K0.0%-15.2%0.266%
5/8/2025 XTX Topco Ltd37,350$216K0.0%N/A0.084%
5/6/2025 KLP Kapitalforvaltning AS8,400$49K0.0%N/A0.019%
4/8/2025 Rhumbline Advisers23,318$135K0.0%+16.6%0.052%
2/28/2025 Universal Beteiligungs und Servicegesellschaft mbH102,749$2.35M0.0%N/A0.231%
2/17/2025 Woodline Partners LP300,000$6.87M0.0%N/A0.676%
2/17/2025 Zimmer Partners LP10,000$229K0.0%N/A0.023%
2/17/2025 Soleus Capital Management L.P.675,409$15.47M1.0%N/A1.521%
2/17/2025Nuveen Asset Management LLC23,961$549K0.0%N/A0.054%
2/17/2025 OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC12,118$278K0.0%N/A0.027%
2/17/2025 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.10,519$241K0.0%N/A0.024%
2/17/2025 Janus Henderson Group PLC1,096,302$25.11M0.0%N/A2.469%
2/17/2025 Deutsche Bank AG10,419$239K0.0%N/A0.023%
2/17/2025 Deerfield Management Company L.P. Series C861,814$19.74M0.4%N/A1.941%
2/17/2025 Driehaus Capital Management LLC2,589,553$59.30M0.5%N/A5.832%
2/17/2025 Deep Track Capital LP1,912,929$43.81M1.6%N/A4.308%
2/17/2025 Casdin Capital LLC553,268$12.67M0.8%N/A1.246%
2/17/2025 BVF Inc. IL2,452,024$56.15M1.9%N/A5.523%
2/17/2025 Bank of America Corp DE78,744$1.80M0.0%N/A0.177%
2/17/2025 BNP Paribas Financial Markets2,251$52K0.0%N/A0.005%
2/17/2025 Alyeska Investment Group L.P.35,000$802K0.0%N/A0.079%
2/17/2025 ArrowMark Colorado Holdings LLC147,886$3.39M0.0%N/A0.333%
2/14/2025 RA Capital Management L.P.6,995,858$160.21M2.1%N/A15.756%
2/14/2025 Jane Street Group LLC26,208$600K0.0%N/A0.059%
2/14/2025 Samsara BioCapital LLC2,768,520$63.40M8.6%N/A6.235%
2/14/2025 Soros Fund Management LLC10,000$229K0.0%N/A0.023%
2/14/2025 Northern Trust Corp147,776$3.38M0.0%N/A0.333%
2/14/2025 The Manufacturers Life Insurance Company22,095$506K0.0%N/A0.050%
2/14/2025 Adage Capital Partners GP L.L.C.300,000$6.87M0.0%N/A0.676%
2/14/2025 Price T Rowe Associates Inc. MD518,588$11.88M0.0%N/A1.168%
2/14/2025 Avoro Capital Advisors LLC1,110,000$25.42M0.4%N/A2.500%
2/14/2025 Tower Research Capital LLC TRC1,093$25K0.0%N/A0.002%
2/14/2025 TRV GP V LLC6,215,591$142.34M48.4%N/A13.999%
2/14/2025 TRV GP VI LLC3,152,456$72.19M61.7%N/A7.100%
2/14/2025 MetLife Investment Management LLC11,555$265K0.0%N/A0.026%
2/13/2025 Walleye Capital LLC20,204$463K0.0%N/A0.046%
2/13/2025 Barclays PLC28,785$659K0.0%N/A0.065%
2/13/2025 Summit Investment Advisors Inc.1,944$45K0.0%N/A0.004%
2/13/2025 Legal & General Group Plc1,840$42K0.0%N/A0.004%
2/13/2025 Invesco Ltd.12,154$278K0.0%N/A0.027%
2/13/2025 Wells Fargo & Company MN10,651$244K0.0%N/A0.024%
2/12/2025 Geode Capital Management LLC380,577$8.72M0.0%N/A0.857%
2/12/2025 JPMorgan Chase & Co.38,015$871K0.0%N/A0.086%
2/11/2025 Corebridge Financial Inc.9,236$212K0.0%N/A0.021%
2/11/2025 Vanguard Group Inc.985,032$22.56M0.0%N/A2.219%
2/7/2025 PNC Financial Services Group Inc.2,680$61K0.0%N/A0.006%
2/6/2025Lindbrook Capital LLC21,000$481K0.0%N/A0.047%
2/6/2025 M&T Bank Corp16,394$376K0.0%N/A0.037%
2/6/2025 Charles Schwab Investment Management Inc.139,616$3.20M0.0%N/A0.314%
2/4/2025 Bank of New York Mellon Corp38,093$872K0.0%N/A0.086%
1/31/2025 New York State Common Retirement Fund1,400$32K0.0%N/A0.003%
1/30/2025 Rhumbline Advisers19,995$458K0.0%N/A0.045%
1/17/2025 SG Americas Securities LLC8,095$185K0.0%N/A0.018%
(Data available from 1/1/2016 forward)

SEPN Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of SEPN shares?

During the previous two years, 68 institutional investors and hedge funds held shares of Septerna. The most heavily invested institutionals were RA Capital Management L.P. ($160.21M), TRV GP V LLC ($142.34M), Samsara BioCapital LLC ($63.40M), Deep Track Capital LP ($43.81M), BVF Inc. IL ($25.45M), Avoro Capital Advisors LLC ($25.42M), and Janus Henderson Group PLC ($25.11M).Learn more on Septerna's institutional investors.

Which institutional investors have been buying Septerna's stock?

Of the 66 institutional investors that purchased Septerna's stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: RA Capital Management L.P. ($7.00M), TRV GP V LLC ($6.22M), BVF Inc. IL ($4.40M), TRV GP VI LLC ($4.21M), Driehaus Capital Management LLC ($3.12M), Samsara BioCapital LLC ($2.77M), and Deep Track Capital LP ($1.91M).

How much institutional buying is happening at Septerna?

Institutional investors have bought a total of 40,913,845 shares in the last 24 months. This purchase volume represents approximately $823.68M in transactions.

Which of Septerna's major shareholders have been selling company stock?

The following institutional investors have sold Septerna stock in the last 24 months: Soleus Capital Management L.P. ($675.90K), Goldman Sachs Group Inc. ($224.96K), Sio Capital Management LLC ($204.24K), Charles Schwab Investment Management Inc. ($21.17K), and XTX Topco Ltd ($15.02K).

How much institutional selling is happening at Septerna?

Institutional investors have sold a total of 1,141,275 shares in the last 24 months. This volume of shares sold represents approximately $10.89M in transactions.


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This page (NASDAQ:SEPN) was last updated on 9/7/2025 by MarketBeat.com Staff
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