Spero Therapeutics (SPRO) Stock Chart & Stock Price History $1.89 +0.01 (+0.53%) As of 03:15 PM Eastern This is a fair market value price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Spero Therapeutics Stock Price Performance The Spero Therapeutics (SPRO) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has increased 37.96%, with a year-to-date return of 83.50%. In the past month, the stock has decreased 1.05%, reflecting recent market activity. As of the latest close, Spero Therapeutics traded at $1.88 with a market cap of $105.81 million and volume of 289,435 shares. Five years ago, the stock traded at $9.99, representing a 81.08% decrease over that period. At the time, it had a market cap of $211.32 million and a volume of 254,951 shares. Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. 5 Day Performance-3.08%1 Month Performance-1.05%3 Month Performance-33.68%Year-To-Date Performance+83.50%1 Year Performance+37.96%5 Year Performance-81.08% SPRO Stock Chart for Tuesday, September, 16, 2025 SPRO Chart by TradingView Spero Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization09/15/2025$1.90$1.88-1.05%$1.92$1.87289,435 shs$105.81 million09/12/2025$1.95$1.90-2.56%$1.99$1.89391,231 shs$106.93 million09/11/2025$1.94$1.95+0.52%$2.02$1.94286,585 shs$109.75 million09/10/2025$1.98$1.94-2.02%$2.02$1.91357,306 shs$109.17 million09/09/2025$2.00$1.98-1.00%$2.01$1.94222,566 shs$111.43 million09/08/2025$2.15$2.00-6.98%$2.18$1.86518,968 shs$112.56 million09/05/2025$2.14$2.15+0.47%$2.17$2.13175,498 shs$121.00 million09/04/2025$2.08$2.14+2.88%$2.20$2.07520,609 shs$120.44 million09/03/2025$2.05$2.08+1.46%$2.12$2.04291,283 shs$117.05 million09/02/2025$2.07$2.05-0.97%$2.12$2.03416,916 shs$115.37 million Get the Latest News and Ratings for SPRO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 09/01/2025$2.07$2.07$2.07$2.00395,346 shs$116.50 million08/29/2025$2.00$2.07+3.50%$2.07$2.00395,346 shs$116.50 million08/28/2025$1.98$2.00+1.01%$2.04$1.96254,895 shs$112.55 million08/27/2025$1.85$1.98+7.03%$2.01$1.85554,715 shs$111.43 million08/26/2025$1.85$1.85$1.88$1.83161,205 shs$104.12 million08/25/2025$1.87$1.85-1.07%$1.90$1.85185,297 shs$104.11 million08/22/2025$1.86$1.87+0.54%$1.94$1.86301,332 shs$105.23 million08/21/2025$1.83$1.86+1.64%$1.90$1.81536,252 shs$104.68 million08/20/2025$1.84$1.83-0.54%$1.85$1.80441,373 shs$102.99 million08/19/2025$1.91$1.84-3.66%$1.91$1.84367,396 shs$103.55 million08/18/2025$1.91$1.91$1.94$1.89521,166 shs$107.50 million08/15/2025$1.98$1.91-3.54%$1.96$1.851.05 million shs$107.50 million Related Companies Compass Therapeutics Stock Price Chart Eton Pharmaceuticals Stock Price Chart Alumis Stock Price Chart Prothena Stock Price Chart Corvus Pharmaceuticals Stock Price Chart Erasca Stock Price Chart iTeos Therapeutics Stock Price Chart Solid Biosciences Stock Price Chart Astria Therapeutics Stock Price Chart Nanobiotix Stock Price Chart Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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